The Caco-2 cell line was taken from the colon cells of a 72-year-old Caucasian male who had colorectal adenocarcinoma. Caco-2 cells have epithelial morphological characteristics and exhibit adherent cultural properties. Caco-2 cells are suitable transfection hosts, and a Caco-2 Transfection Reagent to transfect Caco-2 cells can be purchased from Altogen Biosystems for the study of colon cancer. The Caco-2 cell line is known to differentiate rapidly and be vulnerable to human immunodeficiency virus 1. Caco-2 products include keratin, retinol binding protein 2, and retinoic acid binding protein 1.
Initially derived from human tissue by Jorgen Fogh, Caco-2 cells are human colorectal adenocarcinoma cells that can serve as transfection hosts, provided that the transfection is done with minimally-intrusive transfection reagents . The cells exhibit in vivo characteristics even in vitro , such as the differentiation into enterocytes that are found in the small intestine. Caco-2 cells produce the correct proteins and enzymes that are found in real tissue, making them optimal candidates for initial drug research and the monitoring of cell physiology after introduced foreign DNA or other nucleic acid sequence.
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